Sodium Hydroxide → HCID 53878167, compound

Participants

Reaction Steps

The mixture of 1.5 g of 4-(4-acetamidophenylmercapto)-3-cinnamylamino-5-sulfamoylbenzoic acid and 15 ml of 2 N aqueous sodium hydroxide is refluxed for 80 minutes under nitrogen. After cooling it is washed with diethyl ether, acidified with glacial acetic acid to a pH of 4-5, the precipitate collected and recrystallized from 75% aqueous ethanol, to yield the 4-(4-aminophenylmercapto)-3-cinnamylamino-5-sulfamoylbenzoic acid of the formula ##SPC15##

Provenance & Evidence