Methyl chloroformate → HCID 5043525, compound

HRID 1576735Notes

Reaction equation

HRID 1576735 reaction equation
[C:1]1(=[O:11])[NH:5][C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[K].[CH3:13][O:14][C:15](Cl)=[O:16]>>[CH3:13][O:14][C:15]([N:5]1[C:1](=[O:11])[C:2]2=[CH:10][CH:9]=[CH:8][CH:7]=[C:3]2[C:4]1=[O:6])=[O:16]

Participants

3

Reactant 2

HCID 6586Methyl chloroformateHCID 24194345Phthalimide potassium salt

Product 1

HCID 5043525HCID 5043525, compound

Procedure

A suspension comprising 25 millimoles of potassium phthalimide and 20 ml of methylchloroformate is refluxed for a period of approximately 31/2 hours. Upon completion of refluxing, the reaction mediuim is cooled, filtered, with insolubles being removed continuously by treatment with hot acteone until only potassium chloride remains. The desired product m.p. 184° - 184.5°C., is obtained from the acetone.

Workup

  1. temperatureis refluxed for a period of approximately 31/2 hours
  2. temperatureUpon completion of refluxing
  3. temperaturethe reaction mediuim is cooled
  4. filtrationfiltered, with insolubles
  5. custombeing removed continuously by treatment with hot acteone until only potassium chloride

Sources & evidence

ORD record
ord-3cb2362fdde641d6b9ac79938eaaa5ef
Source dataset
uspto-grants-1976_09
Patent number
US03982891

Reaction notes

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