HRID1576779

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1004

Phosphoric acid

H3O4P

结构：CCO[C@H]1C[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCOCC5)[C@@]4(C)CC(=O)[C@@H]32)C[C@@H]1O

HCID86734023

未命名化合物

PRODUCTS

生成物

结构：CCO[C@H]1C[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCOCC5)[C@@]4(C)CC(=O)[C@@H]32)C[C@@H]1O.O=P(O)(O)O

HCID86734027

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

2β-Ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (231.2 mg., 0.5 mmole) in ethanol (3 ml) was treated with 0.095M aq.orthophosphoric acid (5.3 ml., 1 equiv) and the resulting solution was evaporated, in vacuo. The residue was dissolved in water (5 ml) and made up to a total solution weight of 23.12 g. to give a 1% aqueous solution of the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f79ce66b06384be7920fb567e1e0ca95
来源数据集: uspto-grants-1976_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US03983111
来源说明: uspto-grants-1976_09

反应 SMILES

[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2].[P:34](=[O:38])([OH:37])([OH:36])[OH:35]>C(O)C.O>[P:34]([OH:38])([OH:37])([OH:36])=[O:35].[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2]