Phosphoric Acid → HCID 86734027, compound

HRID 1576779Notes

Reaction equation

HRID 1576779 reaction equation
[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2].[P:34](=[O:38])([OH:37])([OH:36])[OH:35]>C(O)C.O>[P:34]([OH:38])([OH:37])([OH:36])=[O:35].[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2]

Participants

5

Reactant 2

HCID 1004Phosphoric AcidHCID 86734023HCID 86734023, compound

Product 1

HCID 86734027HCID 86734027, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

2β-Ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (231.2 mg., 0.5 mmole) in ethanol (3 ml) was treated with 0.095M aq.orthophosphoric acid (5.3 ml., 1 equiv) and the resulting solution was evaporated, in vacuo. The residue was dissolved in water (5 ml) and made up to a total solution weight of 23.12 g. to give a 1% aqueous solution of the title compound.

Sources & evidence

ORD record
ord-f79ce66b06384be7920fb567e1e0ca95
Source dataset
uspto-grants-1976_09
Patent number
US03983111

Reaction notes

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