Acetic Acid → HCID 86734028, compound

HRID 1576780Notes

Reaction equation

HRID 1576780 reaction equation
[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2].[C:34]([OH:37])(=[O:36])[CH3:35]>C(O)C>[C:34]([OH:37])(=[O:36])[CH3:35].[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 86734023HCID 86734023, compound

Product 1

HCID 86734028HCID 86734028, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2β-ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (116 mg., 0.25 mmole) in ethanol (2 ml.) was treated with 0.1N aqueous acetic acid (2.5 ml. 0.25 mmole) and the resulting solution was evaporated under vacuum. The residue was treated with water (ca 1 ml.) and the undissolved solid (66 mg.) was removed by filtration. The filtrate was diluted to 5 ml. with distilled water, thereby giving a 1% aqueous solution of the title compound.

Workup

  1. customthe resulting solution was evaporated under vacuum
  2. additionThe residue was treated with water (ca 1 ml.)
  3. customthe undissolved solid (66 mg.) was removed by filtration
  4. additionThe filtrate was diluted to 5 ml

Sources & evidence

ORD record
ord-899a9718125a4c7b83e44bf443dcac5c
Source dataset
uspto-grants-1976_09
Patent number
US03983111

Reaction notes

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