HRID1576780

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

结构：CCO[C@H]1C[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCOCC5)[C@@]4(C)CC(=O)[C@@H]32)C[C@@H]1O

HCID86734023

未命名化合物

PRODUCTS

生成物

结构：CC(=O)O.CCO[C@H]1C[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCOCC5)[C@@]4(C)CC(=O)[C@@H]32)C[C@@H]1O

HCID86734028

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A solution of 2β-ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (116 mg., 0.25 mmole) in ethanol (2 ml.) was treated with 0.1N aqueous acetic acid (2.5 ml. 0.25 mmole) and the resulting solution was evaporated under vacuum. The residue was treated with water (ca 1 ml.) and the undissolved solid (66 mg.) was removed by filtration. The filtrate was diluted to 5 ml. with distilled water, thereby giving a 1% aqueous solution of the title compound.

WORKUP

后处理

customthe resulting solution was evaporated under vacuum
additionThe residue was treated with water (ca 1 ml.)
customthe undissolved solid (66 mg.) was removed by filtration
additionThe filtrate was diluted to 5 ml

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-899a9718125a4c7b83e44bf443dcac5c
来源数据集: uspto-grants-1976_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US03983111
来源说明: uspto-grants-1976_09

反应 SMILES

[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2].[C:34]([OH:37])(=[O:36])[CH3:35]>C(O)C>[C:34]([OH:37])(=[O:36])[CH3:35].[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2]