Water → HCID 121291925, compound

Participants

Reaction Steps

A stirred solution of 3α-hydroxy-3β-methyl-5α-pregnane-11,20-dione (17) (5.0 g., 15.0 mmole) in methanol (300 ml.) was treated with a solution of bromine (1.0 ml.) in methanol (30 ml.) at 0° and at such a rate that the yellow colour of the solution disappeared before further addition of the bromine solution took place. The mixture was then poured into water; the precipitated title compound (2.8 g.) was collected by filtration and dried over P2O5 in vacuo.

Provenance & Evidence