反应详情

21-Acetoxy-5α-pregnane-3,11,20-trione (4.85 g.) in hot methanol (200 ml.) was treated with potassium bicarbonate solution (10%; 20 ml.) and the stirred solution was refluxed under nitrogen for 15 minutes. The cooled reaction mixture was diluted with water and the oily precipitate was extracted into methylene chloride. The extract was washed with water, dried over sodium sulphate and evaporated to a foam (4.3 g.) which was triturated with ether to give title compound (3.07 g.) as white crystals, m.p. 164°-170°.

1. temperaturethe stirred solution was refluxed under nitrogen for 15 minutes
2. customThe cooled reaction mixture
3. extractionthe oily precipitate was extracted into methylene chloride
4. washThe extract was washed with water
5. dry with materialdried over sodium sulphate
6. customevaporated to a foam (4.3 g.) which
7. customwas triturated with ether