Sulfuric Acid → HCID 178435155, compound

HRID 1576805Notes

Reaction equation

HRID 1576805 reaction equation
[OH:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([CH3:9])[S:4][N:3]=1.S(=O)(=O)(O)[OH:11]>>[OH:1][C:2]1[C:6]([C:7](=[O:11])[NH2:8])=[C:5]([CH3:9])[S:4][N:3]=1

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 178435154HCID 178435154, compound

Product 1

HCID 178435155HCID 178435155, compound

Conditions

Temperature
113 °C

Procedure

A mixture of 60 g of 3-hydrox-4-cyano-5-methyl-isothiazole and 150 ml of concentrated sulfuric acid (d = 1.838) was heated for 15 minutes at 113°C and after allowing the temperature to return to 45°C, the mixture was added to ice with stirring. The precipitate formed was recovered by vacuum filtration, was washed with water and then with acetone and dried to obtain 51.5 g of 3-hydroxy-4-carbamoyl-5-methyl-isothiazole melting at 248°-250°C.

Workup

  1. customto return to 45°C
  2. additionthe mixture was added to ice
  3. customThe precipitate formed
  4. filtrationwas recovered by vacuum filtration
  5. washwas washed with water
  6. dry with materialwith acetone and dried

Sources & evidence

ORD record
ord-cded3bab32be4f9192ea3bfc9deca290
Source dataset
uspto-grants-1976_09
Patent number
US03983129

Reaction notes

Loading…