Butylamine → HCID 21510057, compound

HRID 1576820Notes

Reaction equation

HRID 1576820 reaction equation
Cl[C:2]1[C:7]([CH2:8][OH:9])=[CH:6][N:5]=[C:4]2[N:10]([CH2:13][CH3:14])[N:11]=[CH:12][C:3]=12.[CH2:15]([NH2:19])[CH2:16][CH2:17][CH3:18]>>[CH2:15]([NH:19][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][N:5]=[C:4]2[N:10]([CH2:13][CH3:14])[N:11]=[CH:12][C:3]=12)[CH2:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 8007ButylamineHCID 20209064(4-Chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanol

Product 1

HCID 21510057HCID 21510057, compoundYield 87%

Procedure

51 g. of 4-Chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-methanol (0.24 mol.) and 300 ml. of n-butylamine are heated at 100° in an autoclave for seven hours. After cooling, the surplus butylamine is removed by distillation in vacuo and the residue is treated with a total amount of 200 ml. of ether. The etheral solution is evaporated, yielding 51.9 g (87%) of the alcohol, m.p. 60°-72°. Recrystallization with hexane provides the pure 4-butylamino-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-methanol, m.p. 85°-86°.

Workup

  1. temperatureAfter cooling
  2. customthe surplus butylamine is removed by distillation in vacuo
  3. additionthe residue is treated with a total amount of 200 ml
  4. customThe etheral solution is evaporated

Sources & evidence

ORD record
ord-072ef6be259b478887f1a4c1ddafaea8
Source dataset
uspto-grants-1976_09
Patent number
US03983128

Reaction notes

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