HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Xylene → HCID 21510116, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Xylene | HCID 7237 | — |
| Reactant | 3-Amino-1-phenylpropan-1-ol | HCID 121548 | — |
| Reactant | N-(1,4,5,6-Tetrahydropyrimidin-2-yl)nitramide | HCID 412214 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 21510116 | HCID 21510116 | — |
Reaction Steps
A mixture of 8 parts of α-(2-aminoethyl)benzylalcohol, 7.2 parts of 2-(nitramino)-1,4,5,6-tetrahydropyrimidine and 40 parts of xylene is stirred and refluxed for 48 hours with water-separator. Upon cooling the reaction mixture, the product is separated as an oil. The xylene is decanted and the oily product is triturated in diisopropylether. The solid product is filtered off and crystallized from acetone, yielding α-[2-(1,4,5,6-tetrahydro-2-pyrimidinylamino)ethyl]benzylalcohol; m.p. 130°-135°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03983133 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-4867107140ef49bdbfe7188386f1b173 |
| Source note | uspto-grants-1976_09 |