Thionyl Chloride → HCID 21510099, compound

HRID 1576859Notes

Reaction equation

HRID 1576859 reaction equation
Cl.[NH2:2][C:3]1[N:4]([CH2:15][CH2:16]O)[CH:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[Cl:14])[CH2:6][N:7]=1.S(Cl)([Cl:20])=O>C(Cl)(Cl)Cl>[ClH:14].[NH2:2][C:3]1[N:4]([CH2:15][CH2:16][Cl:20])[CH:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[Cl:14])[CH2:6][N:7]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 21510146HCID 21510146, compound

Product 1

HCID 21510099HCID 21510099, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A mixture of 4.15 parts of 2-amino-5-(o-chlorophenyl)-2-imidazoline-1-ethanol hydrochloride in 22.5 parts of chloroform is treated with 3.6 parts of thionyl chloride and the whole is stirred at reflux temperature for 30 minutes. The solvent is evaporated and the residue is taken up in 15 parts of chloroform. The latter is evaporated again, yielding 2-amino-1-(2-chloroethyl)-5 (o-chlorophenyl)-2-imidazoline hydrochloride as a residue.

Workup

  1. temperatureat reflux temperature for 30 minutes
  2. customThe solvent is evaporated
  3. customThe latter is evaporated again

Sources & evidence

ORD record
ord-294672d6f22b4da6b7cee975cb3aa521
Source dataset
uspto-grants-1976_09
Patent number
US03983133

Reaction notes

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