2-(1-Methyl-1H-pyrrol-2-yl)-5-nitro-1,3-benzoxazole → 2-(1-Methyl-1H-pyrrol-2-yl)-1,3-benzoxazol-5-amine

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Reaction Steps

1.5 g of 2-(1-methyl-2-pyrrolyl)-5-nitrobenzoxazole (0.006 mole) and 0.15 g of 10% Pd/C are suspended in 100 ml of 95% EtOH and hydrogenated at 50 psi over a period of 2.5 hr. The catalyst is removed and the EtOH evaporated under vacuum yielding a brown solid. Crystallization from methanol yields 1.15 g of tan crystals, mp 183°-185° (89%).

Provenance & Evidence