Tetrahydrofuran → HCID 14112562, compound

Participants

Reaction Steps

Compound XL is prepared by reacting endo-bicycle[3.1.0]hex-2-ene-6-carboxylic acid methyl ester with diborane in a mixture of tetrahydrofuran and diethyl ether, a reaction generally known in the art, to give endo-bicyclo[3.100]63 hexan-3-ol-6-carboxylic acid methyl ester which is then reacted with dihydropyran in the presence of a catalytic amount of POCl3 to give the desired compound. This is then used as described in said Belgian patent to produce the endo form of bicyclo-ketone XVI.

Provenance & Evidence