HCID 12398534, compound → HCID 12398558, compound

HRID 1576921Notes

Reaction equation

HRID 1576921 reaction equation
C([O:3][C:4]([C:6]1[CH:21]=[CH:20][C:9]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])=[CH:8][CH:7]=1)=[O:5])C>[OH-].[Na+]>[C:4]([C:6]1[CH:7]=[CH:8][C:9]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])=[CH:20][CH:21]=1)([OH:5])=[O:3]

Participants

3

Reactant 1

HCID 12398534HCID 12398534, compound

Product 1

HCID 12398558HCID 12398558, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

4-Ethoxycarbonylphenoxy-(2'-methoxyphenyl) methane (14.3g.; 0.05 mole) in sodium hydroxide (100ml.; 10N) was heated under reflux with vigorous stirring for 18 hr. The mixture was then cooled, filtered and the sodium salt converted to the acid by refluxing with hydrochloric acid (6N) for 3 hours. The product was filtered off and recrystallised from acetic acid M.p. 181°-2°.

Workup

  1. temperatureunder reflux
  2. temperatureThe mixture was then cooled
  3. filtrationfiltered
  4. temperatureby refluxing with hydrochloric acid (6N) for 3 hours
  5. filtrationThe product was filtered off
  6. customrecrystallised from acetic acid M.p. 181°-2°

Sources & evidence

ORD record
ord-ab5e87a527204ad8a9a086fba128a563
Source dataset
uspto-grants-1976_09
Patent number
US03983164

Reaction notes

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