HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-(Chloromethyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Carbonochloridic acid, 4-(chloromethyl)phenyl ester | HCID 13434001 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(Chloromethyl)phenol | HCID 35684 | — |
Reaction Steps
Equimolar quantities of p-chloromethylphenyl chloroformate and dimethyl formamide were reacted at room temperature for one hour in acetonitrile (590 parts acetonitrile for every mole of dimethyl formamide or p-chloromethylphenyl chloroformate). Equimolar quantities of methanol were then added to the immonium salt mixture, and the solution was then stirred for about one half hour (with cooling) at 25°-30°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03983178 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-32f1a8b847864c6982794e800a3fe1a6 |
| Source note | uspto-grants-1976_09 |