m-Chloroperbenzoic acid → HCID 21510434, compound

Participants

Reaction Steps

To a cooled (ice/water) solution of 9.4 g. of 3 -methylthio-5-trifluoromethyl-2-indolinone predissolved in 318 ml. of methylene chloride is added 7.33 g. of m-chloroperoxybenzoic acid in small portions over a period of one minute. The ice/water bath is then removed; and, after eight minutes stirring, the reaction mixture is filtered (after the peracid is dissolved and before the product precipitates). The reaction mixture is stirred for an additional hour during which product precipitates. The product is then collected by filtration. Recrystallization from ethyl acetate/ligroine gives 3-methylsulfinyl- 5-trifluoromethyl-2-indolinone, m.p. 141°-142°C.

Provenance & Evidence