反应详情

A mixture of 3.98 g. (13.5 mmol.) of 2-n-butyl-3-(4-hydroxybenzoyl)benzofuran, 2.0 g. (13.5 mmol.) of N-t-butyl-3-chloroazetidine and 0.54 g. of sodium hydroxide in 75 ml. of ethanol was refluxed for five hours. The reaction mixture was cooled, filtered and 125 ml. of 10% aqueous sodium hydroxide solution was added. The mixture was extracted three times with chloroform, the combined extracts were evaporated to dryness and the residue was chromatographed on alumina with chloroform as eluant to give the title compound.

1. additionA mixture of 3.98 g
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. additionof 10% aqueous sodium hydroxide solution was added
5. extractionThe mixture was extracted three times with chloroform
6. customthe combined extracts were evaporated to dryness
7. customthe residue was chromatographed on alumina with chloroform as eluant