HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 3-(Bromomethyl)-1-ethylpyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (1-Ethylpyrrolidin-3-yl)methanol | HCID 21702849 | — |
| Product | 3-(Bromomethyl)-1-ethylpyrrolidine | HCID 21510495 | — |
Reaction Steps
A mixture of 5.0 g. (0.0388 mol.) of N-ethyl-3-hydroxymethylpyrrolidine and 50 ml. of 48% hydrogen bromide was refluxed for 17 hours. The reaction mixture was cooled, made basic by addition of solid sodium carbonate and extracted twice with methylene chloride. The combined extracts were dried (MgSO4) and evaporated to dryness to give 3-bromomethyl-N-ethylpyrrolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03983245 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-46401e28484943168e6253f41315513d |
| Source note | uspto-grants-1976_09 |