p-Anisoyl chloride → (4-methoxyphenyl)-(2-methyl-1-benzofuran-3-yl)methanone

HRID 1577019Notes

Reaction equation

HRID 1577019 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[CH:6]=1.[C:11](Cl)(=[O:20])[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1>>[CH3:19][O:18][C:15]1[CH:16]=[CH:17][C:12]([C:11]([C:6]2[C:5]3[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=3[O:3][C:2]=2[CH3:1])=[O:20])=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 7477p-Anisoyl chlorideHCID 202632-Methyl-1-benzofuran

Product 1

HCID 11043703(4-methoxyphenyl)-(2-methyl-1-benzofuran-3-yl)methanone

Procedure

2-Methylbenzofuran (7.25 g., 0.055 mol.) was acylated with 15.7 g. (0.092 mol.) of p-anisoyl chloride according to the procedure described in Example 1 to give 3-(4-methoxybenzoyl)-2-methylbenzofuran. Demethylation as previously described gives 3-(4-hydroxybenzoyl)-2-methylbenzofuran.

Sources & evidence

ORD record
ord-41ca1f7f701a4dd4af89c781729b9cba
Source dataset
uspto-grants-1976_09
Patent number
US03983245

Reaction notes

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