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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1577023Generated: November 1, 2026

Acetone → 1-(4-chlorophenyl)-2-phenoxyethanone

https://huagongshe.com/reaction/1577023

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetoneHCID 180—
ReactantPhenolHCID 996—
ReactantPotassium CarbonateHCID 11430—
Reactantp-Chlorophenacyl bromideHCID 68303—
SolventWaterHCID 962—
Product1-(4-chlorophenyl)-2-phenoxyethanoneHCID 1471526—

Reaction Steps

A mixture of 23.3 g. (0.1 mol.) of α-bromo-p-chloroacetophenone, 10.0 g. (0.1 mol.) of phenol and 14.5 g. (0.1 mol.) of potassium carbonate in 65 ml. of dry acetone is refluxed for 12 hours. The reaction mixture is cooled, poured into 500 ml. of water and the precipitate formed is collected by filtration and recrystallized from ethanol to give α-phenoxy-p-chloroacetophenone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03983245
Source datasetuspto-grants-1976_09
ORD IDord-a2befa0a7b754456bbec798a739346d1
Source noteuspto-grants-1976_09