p-Anisoyl chloride → HCID 86734036, compound

HRID 1577029Notes

Reaction equation

HRID 1577029 reaction equation
C(C1OC2C=CC(Br)=CC=2C=1)C1C=CC=CC=1.C(Cl)(=O)C1C=CC(OC)=CC=1.[CH2:29]([C:36]1[O:37][C:38]2[CH:54]=[CH:53][C:52]([Br:55])=[CH:51][C:39]=2[C:40]=1[C:41](=[O:50])[C:42]1[CH:47]=[CH:46][C:45]([O:48][CH3:49])=[CH:44][CH:43]=1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.[C:56]([N:60]1[CH2:63][CH:62](CCl)[CH2:61]1)([CH3:59])([CH3:58])[CH3:57]>>[CH2:29]([C:36]1[O:37][C:38]2[CH:54]=[CH:53][C:52]([Br:55])=[CH:51][C:39]=2[C:40]=1[C:41](=[O:50])[C:42]1[CH:47]=[CH:46][C:45]([O:48][CH2:49][C:61]2[C-:62]=[CH:63][N+:60]=2[C:56]([CH3:59])([CH3:58])[CH3:57])=[CH:44][CH:43]=1)[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

5

Reactant 4

HCID 7477p-Anisoyl chlorideHCID 21435285HCID 21435285, compoundHCID 215104971-tert-Butyl-3-(chloromethyl)azetidineHCID 227689092-Benzyl-5-bromo-1-benzofuran

Product 1

HCID 86734036HCID 86734036, compound

Procedure

2-Benzyl-5-bromobenzofuran is acylated with p-anisoyl chloride as described above, the resulting 2-benzyl-5-bromo-3-(4-methoxybenzoyl)benzofuran is dimethylated and the product thus formed is reacted with N-t-butyl-3-chloromethylazetidine as described in Example 3 to give the title compound.

Workup

  1. customthe product thus formed

Sources & evidence

ORD record
ord-40c0d73d8e344325931b012958e995ae
Source dataset
uspto-grants-1976_09
Patent number
US03983245

Reaction notes

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