4-Butylphenol → HCID 20571557, compound
Reaction equation
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[Br:12]Br>C(O)(=O)C>[Br:12][C:10]1[CH:9]=[C:8]([OH:11])[CH:7]=[CH:6][C:5]=1[CH2:1][CH2:2][CH2:3][CH3:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 40 °C
Procedure
22.5 g (0.15 mol) of commercially available p-n-butylphenol was dissolved in 100 ml glacial acetic acid and was slowly heated to 40° C. 24.5 g (0.153 mol) of bromine was added and the solution was stirred for four hours at 60° C. The glacial acetic acid in the reaction solution was removed by distillation and 31.7 g of 3-bromo-4-n-butylphenol was obtained from the residue by vacuum distillation (85° C./1 mmHg). The yield of 3-bromo-4-n-butylphenol was calculated to be 92.1%.
Workup
- customThe glacial acetic acid in the reaction solution was removed by distillation
Sources & evidence
- ORD record
- ord-89305113062b4b8e8ef537c5d92e6aa3
- Source dataset
- uspto-grants-1981_09
- Patent number
- US04287085
Reaction notes
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