Dimethylformamide → HCID 20571554, compound

Participants

Reaction Steps

9.9 g (0.021 mol) of the (2'-cyano-4'-n-butylphenyl)-3-bromo-4-n-heptyloxybenzoate prepared in Step VI and 4 g of cuprous cyanide were added to 80 ml of N,N-dimethylformamide. The suspension was gently refluxed for four hours. The reaction mixture was cooled to room temperature, poured into a solution of 14.5 g ferric chloride hexahydrate dissolved in a mixed solution of 3.6 ml of concentrated hydrochloric acid and 22 ml of water, and was stirred with heating at 65° C. for 30 minutes in order to decompose any complexes. An organic layer was extracted from the suspension with toluene, was cleaned and was dehydrated. The toluene was distilled off. The residue was recrystallized in ethanol to yield 3.4 g of purified (2'-cyano-4'-n-butylphenyl)-3-cyano-4-n-heptyloxybenzoate. The yield was calculated to be 39.1%.

Provenance & Evidence