N,N-Dimethylaniline → HCID 178429659, compound

Participants

Reaction Steps

The aniline derivative from Step C (3.0 g, 14 mmoles) is allowed to react with 2-chloro-2-imidazoline bisulfate (4.04 g, 20 mmoles) in methanol (60 ml) containing water (10 ml) and N,N-dimethylaniline (2.67 g, 22 mmoles). After 72 hours the reaction is worked up in the manner described in Example 2, except that the initial dichloromethane extracts are evaporated to a residue and triturated with hexane before extraction with 2 N acetic acid. The yield of pure product is 2.95 g, m.p. 140°-141° C.

Provenance & Evidence