Acetyl chloride → HCID 12940596, compound

Participants

Reaction Steps

In this preparation 23.18 g (0.085 mol) of 4-(2-trifluoromethyl-4-chlorophenoxy)-benzene and 6.66 g (0.085 mol) of acetyl chloride are admixed with 200 ml of carbon disulfide and then 27.52 g (0.17 mol) of ferric chloride is added and the resulting mixture stirred at room temperature for about 23 hours. The mixture is then washed three times with ice-water, dried over magnesium sulfite and filtered. The filtrate is evaporated to dryness and the residue chromatographed on a silica gel column eluting with hexane; 5 vol.% tetrahydrofuran-hexane; and then 10 vol.% tetrahydrofuran-hexane, affording 1-acetyl-4-(2-trifluoromethyl-4-chlorophenoxy)-benzene.

Provenance & Evidence