Ethylamine → N-cyano-N'-ethyl-N"-[2-(2-pyrazinylmethylthio)ethyl]guanidine

HRID 1577205Notes

Reaction equation

[CH2:1]([NH2:3])[CH3:2].[C:4]([NH:6][C:7](=[N:10][CH2:11][CH2:12][S:13][CH2:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1)SC)#[N:5]>>[C:4]([NH:6][C:7]([NH:3][CH2:1][CH3:2])=[N:10][CH2:11][CH2:12][S:13][CH2:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1)#[N:5]

Participants

Reactant 2

HCID 6341Ethylamine

HCID 20567491N-cyano-N'-[2-(2-pyrazinylmethylthio)ethyl]S-methylisothiourea

Product 1

HCID 53864220N-cyano-N'-ethyl-N"-[2-(2-pyrazinylmethylthio)ethyl]guanidine

Procedure

Anhydrous ethylamine is reacted with N-cyano-N'-[2-(2-pyrazinylmethylthio)ethyl]-S-methylisothiourea by the procedure of Example 4 to give N-cyano-N'-ethyl-N"-[2-(2-pyrazinylmethylthio)ethyl]guanidine.

Sources & evidence

ORD record: ord-f65dc33fbbbd4091a105e70479d26dc2
Source dataset: uspto-grants-1981_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04287198

Reaction notes

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