HCID 20572046, compound → HCID 20572047, compound

Participants

Reaction Steps

To 22 g of 5-bromo-2,2,4,4-tetramethyl pentane nitrile in 60 ml of anhydrous ether, 0.1 mol of methyl lithium in solution in 200 ml of anhydrous ether is added drop by drop in an inert atmosphere. The reaction medium is maintained between 0° and 5° C. during the addition and then for an additional 30 minutes and then kept at room temperature for 4 hours. After hydrolysis, the aqueous phase is extracted with ether. The 2,3,3,5,5-pentamethyl-3,4,5,6-tetrahydropyridine is then isolated by distillation. There is obtained a colorless liquid of B.P.10 -2 =43° C. in a yield of 70% of Δ1-piperideine.

Provenance & Evidence