Chlorosulfonic acid → HCID 20572211, compound

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Reaction Steps

A mixture of 1.00 grams of 2-amino-4-methyl-6-(3,6-dihydro-1-(2H)-pyridinyl) pyrimidine-3-oxide, 1.15 grams of chlorosulfonic acid, and 2.50 grams of di-isopropylethylamine in 25 mls of chloroform is stirred overnight. The mixture is concentrated and the residue is stirred with aqueous sodium bicarbonate, filtered, and washed with ether to give 2-amino-6-methyl-4-(3,6-dihydro-1(2H)-pyridinyl)-1-(sulfooxy)-pyrimidinium hydroxide, inner salt.

Provenance & Evidence