Chlorosulfonic acid → HCID 20572143, compound

Participants

Reaction Steps

A mixture of 1.00 grams of 2,4-diamino-6-(4-methyl-1-piperazinyl)pyrimidine-3-oxide, 1.50 grams of chlorosulfonic acid, and 2.5 grams of di-isopropylethylamine in 25 ml of chloroform is stirred overnight. The mixture is concentrated in vacuo. The residue is stirred with aqueous sodium bicarbonate, filtered and washed with ether to give the crude product. This is recrystallized from DMF and ethyl acetate to yield the purified 2,6-diamino-4-(4-methyl-1-piperazinyl)-1-(sulfooxy)pyrimidinium hydroxide, inner salt.

Provenance & Evidence