反应详情

A mixture of 2-chloro-4-amino-7,8-dimethoxyquinazoline (3.00 g., 12.5 mmoles) and 1-(2-furoyl)piperazine (2.71 g., 15.0 mmoles) was refluxed in 80 ml. isoamyl alcohol for two hours and then cooled in an ice-bath. The resulting white product was collected by filtration and recrystallized from methanol/ether to yield 4.53 g. (79%) of pure final product, M.P. 251° C. The water solubility was found to be 20 mg./ml.

1. temperaturewas refluxed in 80 ml
2. temperaturecooled in an ice-bath
3. filtrationThe resulting white product was collected by filtration
4. customrecrystallized from methanol/ether
5. customto yield 4.53 g