4-Hydroxypyrrolidine → HCID 20506397, compound

HRID 1577326Notes

Reaction equation

HRID 1577326 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([O:15][CH3:16])[C:8]([O:13][CH3:14])=[C:9]([Cl:12])[CH:10]=2)[N:5]=[C:4](Cl)[N:3]=1.[NH:18]1[CH2:22][CH2:21][CH:20]([OH:23])[CH2:19]1>C(O)CC(C)C>[ClH:12].[OH:23][CH:20]1[CH2:21][CH2:22][N:18]([C:4]2[N:3]=[C:2]([NH2:1])[C:11]3[C:6](=[C:7]([O:15][CH3:16])[C:8]([O:13][CH3:14])=[C:9]([Cl:12])[CH:10]=3)[N:5]=2)[CH2:19]1

Participants

4

Reactant 2

HCID 982104-HydroxypyrrolidineHCID 12920006HCID 12920006, compound

Product 1

HCID 20506397HCID 20506397, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

A mixture of 4-amino-2,6-dichloro-7,8-dimethoxyquinazoline (5.48 g., 0.020 mole) and 3-pyrrolidinol (2.18 g., 0.025 mole) in 150 ml. of isoamyl alcohol is heated at reflux for five hours then cooled in ice. The precipitated product is collected by filtration and purified by recrystallization to obtain the title compound.

Workup

  1. temperatureat reflux for five hours
  2. temperaturethen cooled in ice
  3. filtrationThe precipitated product is collected by filtration
  4. custompurified by recrystallization

Sources & evidence

ORD record
ord-e73f2ee567de4dc4a057fedf431008d4
Source dataset
uspto-grants-1981_09
Patent number
US04287341

Reaction notes

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