Morpholine → 2-(Morpholin-4-yl)-4-amino-7,8-dimethoxyquinazoline hydrochloride

HRID 1577333Notes

Reaction equation

HRID 1577333 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([O:14][CH3:15])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[C:4]([Cl:16])[N:3]=1.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>CC(CC)=O>[ClH:16].[N:17]1([C:4]2[N:3]=[C:2]([NH2:1])[C:11]3[C:6](=[C:7]([O:14][CH3:15])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[N:5]=2)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 129200082-Chloro-4-amino-7,8-dimethoxyquinazoline

Product 1

HCID 205063952-(Morpholin-4-yl)-4-amino-7,8-dimethoxyquinazoline hydrochloride

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

To 500 ml. of methylethylketone is added 0.1 mole of 4-amino-2-chloro-7,8-dimethoxyquinazoline and 0.12 mole of morpholine and the mixture is refluxed overnight. After cooling in ice-water the solid precipitated is collected by filtration, washed with ether and air dried to obtain the title compound.

Workup

  1. temperaturethe mixture is refluxed overnight
  2. customprecipitated
  3. filtrationis collected by filtration
  4. washwashed with ether and air
  5. customdried

Sources & evidence

ORD record
ord-da04e3c8073c480fa774248f7776c1ed
Source dataset
uspto-grants-1981_09
Patent number
US04287341

Reaction notes

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