Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | 6-Chloronicotinamide | HCID 80456 | — |
| Reactant | HCID 86737988 | HCID 86737988 | — |
| Product | HCID 12862362 | HCID 12862362 | — |
Reaction Steps
A mixture of 6.0 g (0.038 mol) of 6-chloro-3-pyridinecarboxamide (Aldrich Chemical Company) and 10.0 g (0.054 mol) of 2-amino-3-methyl-3-thiophenecarboxylic acid, ethyl ester (Chemische Berichte, Vol. 99, pages 94-100, 1966) is heated in an oil bath at 185° C. for one hour then at 135°-140° C. for sixteen hours and finally at 195° C. for six hours. The mixture is cooled and then suspended in hot chloroform and filtered to give 0.6 g of 2-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide; mp 350°-354° C. after recrystallization from pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04287340 |
|---|
| Source dataset | uspto-grants-1981_09 |
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| ORD ID | ord-0317a6f1ea8b4087833f47c67d9e6a4f |
|---|
| Source note | uspto-grants-1981_09 |
|---|
