HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetate → 4-oxo-2-phenyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetate | HCID 175 | — |
| Reactant | 6-Chloronicotinamide | HCID 80456 | — |
| Reactant | ethyl 2-amino-5-phenylthiophene-3-carboxylate | HCID 638860 | — |
| Product | 4-oxo-2-phenyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide | HCID 12862367 | 4.1% |
Reaction Steps
From 4.7 g (0.030 mol) of 6-chloro-3-pyridinecarboxamide (Aldrich Chemical Company) and 7.5 g (0.030 mol) of 2-amino-5-phenyl-3-thiophenecarboxylic acid, ethyl ester (Chemische Berichte, Vol. 99, pages 94-100, 1966), following the procedure of Example 22, there is obtained 0.4 g of 4-oxo-2-phenyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide, monoacetate; mp 348°-352° C. after recrystallization from glacial acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04287340 |
| Source dataset | uspto-grants-1981_09 |
| ORD ID | ord-64389b5b46e64b40bb42bc0319f198e4 |
| Source note | uspto-grants-1981_09 |