反应详情

Into a 500 ml four-necked flask, there were charged methylisobutylketone (150 ml), α,α-dimethylbenzylamine (33.8 g) and triethylamine (27.8 g), and α-bromo-tert-butylacetylbromide (64.5 g) was dropwise added thereto while stirring at room temperature. Stirring was continued for 3 hours. After completion of the reaction, water (200 ml) was added thereto and the reaction mixture was gradually heated to remove methylisobutylketone, followed by cooling at room temperature. The precipitated crystals were filtered, washed with water, dried and recrystallized from ethanol to give N-(α,α-dimethylbenzyl)-α-bromo-tert-butylacetamide (61.5 g).

1. additionwas dropwise added
2. stirringStirring
3. additionwas added
4. temperaturethe reaction mixture was gradually heated
5. customto remove methylisobutylketone
6. temperatureby cooling at room temperature
7. filtrationThe precipitated crystals were filtered
8. washwashed with water
9. customdried
10. customrecrystallized from ethanol