Dimethylamine → HCID 20570904, compound

HRID 1577500Notes

Reaction equation

HRID 1577500 reaction equation
C[O-].[Na+].[CH3:4][CH:5]([C:7]1[CH:11]=[CH:10][O:9][C:8]=1[C:12]([O:14]C)=O)[CH3:6].[CH3:16][NH:17][CH3:18]>CO>[CH3:16][N:17]([CH3:18])[C:12]([C:8]1[O:9][CH:10]=[CH:11][C:7]=1[CH:5]([CH3:6])[CH3:4])=[O:14]

Participants

5

Reactant 3

HCID 674DimethylamineHCID 10942334Sodium MethoxideHCID 67355685HCID 67355685, compound

Product 1

HCID 20570904HCID 20570904, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of sodium methoxide (3.3 g) and 3-(1-methylethyl)-2-furancarboxylic acid, methyl ester (14 g) in dry methanol (50 ml) was treated with dimethylamine gas during 2 hours. The solvent was removed in vacuo and the residue was dissolved in diethyl ether (150 ml) and washed with water (100 ml). The ethereal extract was dried over anhydrous sodium sulphate and evaporation of the solvent gave the title compound (12 g) as an oil.

Workup

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in diethyl ether (150 ml)
  3. washwashed with water (100 ml)
  4. extractionThe ethereal extract
  5. dry with materialwas dried over anhydrous sodium sulphate and evaporation of the solvent

Sources & evidence

ORD record
ord-48cb1121fc8d471d9d946acb7638b45d
Source dataset
uspto-grants-1981_09
Patent number
US04288443

Reaction notes

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