反应详情

A solution of 5-[[2-(amino)ethyl]thio]methyl-N,N,3-trimethyl-2-furanmethanamine (1.14 g) and N-nitro-S-methyl-isothiourea (0.65 g) in ethanol (10 ml) was warmed for 5 minutes and stirred for 30 minutes at ambient temperature. The solvent was removed in vacuo and the residue purified by column chromatography (silica/methanol: 0.88 ammonia 100:1). The resulting oil was triturated with petroleum ether (40°-60°) and the solid residue crystallised from toluene yielding the title compound (0.5 g) as a white powder m.p. 84°-85°.

1. customThe solvent was removed in vacuo
2. customthe residue purified by column chromatography (silica/methanol: 0.88 ammonia 100:1)
3. customThe resulting oil was triturated with petroleum ether (40°-60°)
4. customthe solid residue crystallised from toluene yielding the title compound (0.5 g) as a white powder m.p. 84°-85°