Ammonia → HCID 178510728, compound

HRID 1577529Notes

Reaction equation

HRID 1577529 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([C:8]2[S:12][C:11]3[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=3[C:9]=2[OH:17])=O)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)(Cl)Cl.[NH3:26]>CO>[NH2:26]/[C:6](/[C:5]1[CH:18]=[CH:19][C:2]([F:1])=[CH:3][CH:4]=1)=[C:8]1\[C:9](=[O:17])[C:10]2[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=2[S:12]\1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 24819Phosphorus pentachlorideHCID 136058917HCID 136058917, compound

Product 1

HCID 178510728HCID 178510728, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared as in Example 1 from 2-(4-fluorobenzoyl)-benzo[b]thiophen-3-ol, phosphorus(V) chloride and concentrated ammonia with a yield of 63% of theory. Yellow, felt-like crystals; M.p. 158° C. (methanol).

Sources & evidence

ORD record
ord-819e3bb5f11348c9961c940d90c24202
Source dataset
uspto-grants-1981_09
Patent number
US04288437

Reaction notes

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