Ammonia → HCID 178510721, compound

HRID 1577531Notes

Reaction equation

HRID 1577531 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([C:6]1[S:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[C:7]=1[OH:15])=O.P(Cl)(Cl)(Cl)(Cl)Cl.[NH3:26]>C1(C)C=CC=CC=1>[NH2:26]/[C:4](/[C:3]1[CH:16]=[CH:17][CH:18]=[CH:19][C:2]=1[F:1])=[C:6]1\[C:7](=[O:15])[C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[S:10]\1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 24819Phosphorus pentachlorideHCID 20570760HCID 20570760, compound

Product 1

HCID 178510721HCID 178510721, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

Prepared as in Example 1 from 2-(2-fluorobenzoyl)benzo[b]-thiophen-3-ol, phosphorus(V) chloride and concentrated ammonia, but using a mixture of toluene and petroleum ether in a volume ratio of 2:1 in place of pure toluene, giving a yield of 50% of theory. Yellow crystals; m.p. 156°-158° C. (ethyl acetate/petroleum ether 1:1).

Workup

  1. customgiving a yield of 50% of theory

Sources & evidence

ORD record
ord-5c6f5dfbbb1e4dc8bdb881994640a15d
Source dataset
uspto-grants-1981_09
Patent number
US04288437

Reaction notes

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