Ammonia → HCID 178510726, compound

HRID 1577533Notes

Reaction equation

HRID 1577533 reaction equation
[OH:1][C:2]1[C:3]2[CH:18]=[CH:17][CH:16]=[CH:15][C:4]=2[S:5][C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)=O.P(Cl)(Cl)(Cl)(Cl)Cl.[NH3:25]>>[NH2:25]/[C:7](/[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)=[C:6]1\[C:2](=[O:1])[C:3]2[CH:18]=[CH:17][CH:16]=[CH:15][C:4]=2[S:5]\1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 24819Phosphorus pentachlorideHCID 20570780HCID 20570780, compound

Product 1

HCID 178510726HCID 178510726, compoundYield 27%

Procedure

Prepared as in Example 1 from (3-hydroxybenzo-[b]thien-2-yl)-2-pyridinyl-methanone, phosphorus(V) chloride and concentrated ammonia with a yield of 27% of theory. M.p. 128°-130° C. (ethyl acetate) C14H10N2OS (254.30): Calc.: C-66.12%; H-3.96%; N-11.02%; S-12.61%; Found: C-66.34%; H-4.09%; N-11.45%; S-12.70%.

Sources & evidence

ORD record
ord-aec6324c3c1f4763a70fbd79d1cb1610
Source dataset
uspto-grants-1981_09
Patent number
US04288437

Reaction notes

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