Hydrochloric Acid → Benzenesulfonamide, 4-amino-N-(thioxo(tricyclo(3.3.1.1(sup 3,7))dec-1-ylamino)methyl)-

Participants

Reaction Steps

A suspension of 28.25 g. (0.070 mol) of 1-adamantyl-3-(4-acetamidophenylsulfonyl)thiourea and 28 g. (0.70 mol) of sodium hydroxide in 500 ml. of water was refluxed for 1 hour. On cooling, the pH of the mixture was adjusted to 1 by dropwise addition of 6 N hydrochloric acid and the precipitate was recrystallized from methanol-water to give 20.8 g. (83%) of the (aminophenylsulfonyl)thiourea, m.p. 176°-179°.

Provenance & Evidence