Butanoic acid, 2-bromo-, ethyl ester → Ethyl-alpha-(2,2,2-trifluoro-1-phenylethoxy)butyrate

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Reaction Steps

10.3 g of the sodium-2,2,2-trifluoro-1-phenylethanolate, obtained according to the process of Step A, are transferred into a three-neck flask with 50 ml dimethylformamide. After complete mixing, there is slowly added while cooling with an ice-bath a cooled mixture of 9.4 g ethyl-2-bromobutyrate and 35 ml dimethylformamide. The reaction is strongly exothermic and external cooling is applied so that the temperature of the reaction mixture does not go over 20°. The stirring and the cooling of the mixture are kept for four days.

Provenance & Evidence