Sulfuric Acid → HCID 20569331, compound

Participants

Reaction Conditions

Reaction Steps

Sulfuric acid, 85% concentration, (40 grams) is charged into a glass reaction vessel fitted with a mechanical stirrer and thermometer and is cooled to about 5° C. N-(5,5,7,7-tetramethyl-4,5,6,7-tetrahydrobenzothiazol-2-yl)-N'-hexylurea (0.015 mole) and s-trioxane (0.015 mole) are added portionwise, with stirring to the cold sulfuric acid. Stirring is continued for a period of about 16 hours at room temperature. The reaction mixture is then diluted 1:1 with water and neutralized with aqueous 40% sodium hydroxide. The neutralized mixture is filtered and the filtered-off solid is washed with 3-100 ml portions of water and air dried to yield the desired product 3-(5,5,7,7-tetramethyl-4,5,6,7-tetrahydrobenzothiazol-2-yl)-5-hexyltetrahydro-1,3,5-oxadiazin-4-one.

Provenance & Evidence