反应详情

2-Amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydrobenzothiazole (0.3mole), potassium cyanate (0.3 mole) and concentrated acetic acid (90 ml) are charged into a glass reaction vessel fitted with a mechanical stirrer and thermometer. A mild exotherm is noted at the beginning of the reaction. Stirring is continued for a period of about 1 hour with no external heating. Water (90 ml) is added and the resulting mixture filtered. The filtered-off solids are recrystallized from methanol to yield the desired product N-(5,5,7,7-tetramethyl-4-5,6,7-tetrahydrobenzothiazol-2-yl)urea.

1. customfitted with a mechanical stirrer
2. customA mild exotherm is noted at the beginning of the reaction
3. filtrationthe resulting mixture filtered
4. customThe filtered-off solids are recrystallized from methanol