Toluene → HCID 12783486, compound

HRID 1577813Notes

Reaction equation

HRID 1577813 reaction equation
[CH:1](=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].Cl.[NH2:14][CH2:15][CH2:16][SH:17].C1(C)C=CC=CC=1>O>[CH2:2]([CH:1]1[NH:14][CH2:15][CH2:16][S:17]1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

Participants

5

Reactant 3

HCID 1140TolueneHCID 8186UndecanalHCID 9082Cysteamine Hydrochloride

Product 1

HCID 12783486HCID 12783486, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 34 g. of undecylaldehyde and 22.8 g. of 2-aminoethanethiol hydrochloride in about 400 ml. of toluene was heated at reflux overnight. The water of condensation was collected in a Dean-Stark trap. The reaction mixture then was washed with aqueous sodium hydroxide and dried over anhydrous magnesium sulfate. After filtering the reaction mixture, the toluene was distilled under reduced pressure. The residue then was vacuum distilled, b.p. 130°-8°/0.1 mm, giving 2-decylthiazolidine. The following elemental microanalysis was obtained:

Workup

  1. additionA mixture of 34 g
  2. temperatureat reflux overnight
  3. customwas collected in a Dean-Stark trap
  4. washThe reaction mixture then was washed with aqueous sodium hydroxide
  5. dry with materialdried over anhydrous magnesium sulfate
  6. filtrationAfter filtering the reaction mixture
  7. distillationthe toluene was distilled under reduced pressure
  8. distillationdistilled

Sources & evidence

ORD record
ord-37360e063b4e4878bb9b3ca165f12e9b
Source dataset
uspto-grants-1981_09
Patent number
US04289766

Reaction notes

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