Methyl iodide → HCID 20570062, compound

Participants

Reaction Steps

The reaction is performed according to example 15 from 3-(n-butyl)-7-(6'-oxoheptyl)-xanthine and methyl iodide, but at a temperature of the mixture of 50° C. under stirring for 46 hours. Prior to the distillation at a bath temperature of 140° C. and 0.02 mmHg the product is purified by column chromatography at silica gel 60 (Merck) with methylene chloride/acetone (80:2) as eluent. 1-Methyl-3-(n-butyl)-7-(6'-oxoheptyl)-xanthine was obtained as a viscous oil (nD20 1.5280; yield 80.1%, referred to reacted 3-(n-butyl)-7-(6'-oxoheptyl)-xanthine.

Provenance & Evidence