m-Chloroperbenzoic acid → HCID 178477626, compound

Participants

Reaction Conditions

Reaction Steps

3.2 gm of 5-amino-2-(2'-ethylmercapto-ethylamino)4-hydroxy-pyrimidine (0.015 mol) were dissolved in a mixture of 60 ml of absolute methanol and 60 ml of absolute methylene chloride. The solution was admixed with a solution of 2.89 gm (0.015 mol) of m-chloro-perbenzoic acid in 50 ml of methylene chloride at -15° C. After stirring for 8 hours at 0° C., the mixture was evaporated in vacuo to nearly dryness and was fractionated on a silicagel column with a methylene chloride/methanol mixture of at first 10:1, then 5:1. 1.42 gm (41.1%) of a uniform product were obtained.

Provenance & Evidence