Triethylamine → HCID 20569907, compound

Participants

Reaction Steps

4-(N-methylamino)-1-benzylpiperidine dihydrochloride (41.4 g) (prepared as in German Offenlegungsschrift No. 2341376), triethylamine (30.2 g) and n-propylisocyanate (12.7 g) in chloroform (200 ml) were mixed together then allowed to stand overnight. The resulting solution was then washed with water (3×100 ml), and, after separation, the chloroform layer was dried and evaporated to leave an oil which on crystallization from petrol (b.p. 60°-80°) gave, 3-n-propyl-1-methyl-1-(1-benzyl-4-piperidyl)urea (42.0 g), m.p. 84°-86°.

Provenance & Evidence