Methanol → HCID 12881939, compound

Participants

Reaction Steps

A mixture of ethyl 10,11-dihydrodibenz[b,f][1,4]oxazepine-8-carboxylate (5.4 g), potassium hydroxide (1.1 g), methanol (70 ml) and water (5 ml) was refluxed for 3 hours. After distilling off the solvents under reduced pressure, the residue was dissolved in distilled water (20 ml). The solution was washed with ethyl acetate and acidified with diluted hydrochloric acid. The separated crystals were collected by filtration and then recrystallized from methanol to give 10,11-dihydrodibenz[b,f][1,4]oxazepine-8-carboxylic acid.

Provenance & Evidence