Potassium Carbonate → HCID 12773835, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of cis-5-(3,4-dimethoxyphenyl)proline hydrochloride (8.0 g., 0.028 m) and sodium hydroxide (2.22 g., 0.055 m) in water (50 ml.) at 10° C., was slowly added 3-bromopropionyl chloride (2.80 ml., 0.028 m) along with sodium hydroxide (1.11 g., 0.028 m) in water (25 ml.), keeping pH between 7.5 and 9. This mixture was stirred at 25° C. overnight. Potassium thioacetate, prepared by mixing thiolacetic acid (1.50., 0.021 m) and potassium carbonate (1.75 g., 0.012 m) in water (15 ml.) was added to the reaction which was stirred overnight at 25° C. to afford the title compound, which was employed without isolation as the reactant in the following example.

Provenance & Evidence