1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → HCID 56615316, compound

HRID 1578027Notes

Reaction equation

HRID 1578027 reaction equation
C(O[C@:5]1([C@:25]2([CH3:26])[C@H:11]([C@H:12]3[C@H:22]([CH2:23][C@@H:24]2[Cl:27])[C@:20]2([CH3:21])[C:15](=[CH:16][C:17](=O)[C@@H:18]4[CH2:28][C@@H:19]42)[CH:14]=[CH:13]3)[CH2:10][CH2:9]1)[C:6](=O)[CH3:7])(=O)C.C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>>[Cl:27][C@@H:24]1[C@@:25]2([CH3:26])[C@@H:11]([CH2:10][CH:9]=[C:5]2[CH2:6][CH3:7])[C@H:12]2[C@@H:22]([C@:20]3([CH3:21])[C:15]([CH:14]=[CH:13]2)=[CH:16][CH2:17][C@@H:18]2[CH2:28][C@H:19]32)[CH2:23]1

Participants

3

Reactant 2

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)HCID 70540197HCID 70540197, compound

Product 1

HCID 56615316HCID 56615316, compoundYield 63.4%

Procedure

One gram of 17α-acetoxy-12α-chloro-1α,2α-methylene-4,6-pregnadiene-3,20-dione is treated analogously to Example 1 in "Dowtherm" for 1 hour at 280° C. and worked up. Recrystallization from isopropyl ether yields 500 mg of 12α-chloro-1α,2α-methylene-4,6,16-pregnatriene (61% of theory).

Workup

  1. customRecrystallization from isopropyl ether

Sources & evidence

ORD record
ord-df7dde4378ab4294ba4b4a7083f64338
Source dataset
uspto-grants-1981_09
Patent number
US04290963

Reaction notes

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